Selected Publications

2024

1.  Samrat, Subodh Kumar, et al. "An ISG15-Based High-Throughput Screening Assay for Identification and Characterization of SARS-CoV-2 Inhibitors Targeting Papain-Like Protease." Viruses 16.8 (2024): 1239.

2023

1. Liang W, Gu M, Zhu L, Yan Z, Schenten D, Herrick S, Li H, Samrat SK, Zhu J, Chen Y (2023). The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression, Sig. Transduct. Target. Ther. 8, 162.
2. Samrat SK, Bashir Q, Huang Y, Liu Y, Wu X, Brown T, Wang W, Zheng YG, Zhang QY, Chen Y, Li Z, Li H † (2023), A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases, Emerg Microbes Infect, 12(1):2204164. DOI: 10.1080/22221751.2023.2204164
3. Samrat SK Bashir Q, Huang Y, Trieshmann CW, Tharappel AM, Zhang R, Chen K, Zheng YG, Li Z, Li H † (2023), Broad-spectrum small-molecule inhibitors targeting the SAM-binding site of flavivirus NS5 methyltransferase, ACS infect Dis, 9, 1319–1333.
4. Xu J, Xue Y, Bolinger AA, Zhou M, Chen H, Li H, Zhou J (2023), Therapeutic potential of salicylamide derivatives for combating viral infections, Medicinal Research Reviews, 43(4):897-931

2022

1. Li Z, Xu J, Lang Y, Wu X, Hu S, Samrat SK, Tharappel AM, Kuo L, Butler D, Song Y, Zhang QY, Zhou J, Li H ^† (2022). In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus, Acta Pharm Sin B, 12(4), 1662-1670
2. Samrat SK, Xu J, Xie X, Gianti E, Chen H, Zou J, Pattis JG, Elokely K, Lee H, Li Z, Klein ML, Shi PY, Zhou J, Li H ^† (2022). Allosteric inhibitors of the main protease of SARS-CoV-2. Antiviral Res. 2022 Jul 11;205:105381. doi: 10.1016/j.antiviral.2022.105381.
3. Tharappel AM, Li Z, Zhu Y, Wu X, Chaturvedi S, Zhang Q, Li H ^† (2022). Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 Intein Splicing. ACS Infect Dis, https://pubs.acs.org/doi/full/10.1021/acsinfecdis.2c00137.
4. Xu J, Xue Y, Zhou R, Shi PY, Li H, and Zhou J. (2021), Small Molecule Therapeutic Approaches to Combating Coronavirus: Potential Drugs and Drug Targets, Medical Research Reviews, 41:1375–1426.
5. Tharappel A, Li Z, Li H ^† (2022), Inteins as drug targets and therapeutic tools, Frontiers in Mol Biosci, https://doi.org/10.3389/fmolb.2022.821146.
6. Samrat SK, Xu J, Li Z, Zhou J, Li H ^† (2022), Antiviral agents against flavivirus proteases: prospect and future direction, Pathogens, 11(3): 293. https://doi.org/10.3390/pathogens11030293
7. Wang J ^†, Li H ^† (2022). Editorial of Special Column on Antiviral Drug Discovery and Pharmacology. Acta Pharm Sin B. 2022 Apr;12(4):1540-1541.

2021

1. Li Z, Tharappel AM, Xu J, Lang Y, Green CM, Zhang J, Lin Q, Chaturvedi S, Zhou J, Belfort M, Li H (2021),Small molecule inhibitors for the Prp8 intein as antifungal agents, Proc. Natl. Acad. Sci. U.S.A, 118 (2), e2008815118.
2. Williams JE, Jaramillo MV, Li Z, Zhao J, Wang C, Royer WE, von Roey P, Li H, Milles KV (2021), The splicing activity and an alternative domain-swapped structure of the pyrococcus horikoshii PolII mini-intein, Sci Rep, 11, 11680

2020

1. Woods D, Vangaveti S, Egbanum I, Sweeney AM, Li Z, Bacot-Davis V, LeSassier DS, Stanger M, Hardison GE, Li H, Belfort M, Lennon CW (2020). Conditional DnaB protein splicing is reversibly inhibited by zinc in mycobacteria. mBio. 11, e01403-20.
2. Li Z, Xu J, Lang Y, Fan X, Kuo L, D'Brant L, Hu S, Samrat SK, Trudeau N, Tharappel AM, Rugenstein N, Koetzner CA, Zhang J, Chen H, Kramer LD, Butler D, Zhang Q, Zhou J, Li H (2020), JMX0207, a niclosamide derivative with improved pharmacokinetics, suppresses Zika virus infection both in vitro and in vivo, ACS Infect Dis, 6, 2016-28.
3. Li Z, Lang Y, Sakamuru S, Samrat SK, Trudeau N, Kuo L, Rugenstein N, Tharappel AM, D'Brant L, Koetzner CA, Hu S, Zhang J, Huang R, Kramer LD, Butler D, Xia M, Li H (2020), Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo, Emerging Microbes and Infections, 9(1), 2404-2416.

2019

1. Li Z, Fu B, Green CM, Lang Y, Zhang J, Li X, Chaturvedi S, Belfort M, Liao G^†, Li H (2019), Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein splicing, Emerging Microbes and Infections, 8(1):895-908.
2. Green CM, Li Z, Smith AD, Novikova O, Bacot-Davis VR, Gao F, Hu S, Banavali NK, Thiele DJ, Li H, Belfort M (2019), Spliceosomal Prp8 intein at the crossroads of protein and RNA splicing, Plos Biol, doi: 10.1371/journal.pbio.3000104.
3. Zhao J, Ciulla DA, Xie J, Wagner AG, Castillo DA, Zwarycz AS, Lin Z, Giner JL, Li Z, Li H, Banavali N, Callahan BP, Wang C (2019), General base swap preserves activity and expands substrate tolerance in hedgehog autoprocessing, J. Am. Chem. Soc., 141:18380-18384.
4. Cho JJ, Mansouri S, Drashansky TT, Helm EY, Zuniga AN, Xu Z, Parthasarathy U, Lorentsen KJ, Uddin MN, Duong DM, Edelmann MJ, Gehring T, Krappmann D, Califano D, Li H, Wang RL, Cho JY, Jin L, Zhou L, Avram D (2019), E3 ubiquitin ligase Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling, Nat Comm., 10, 701; doi: 10.1038/s41467-019-08605-3

2018

1. Kelley DS, Lennon CW, Li Z, Miller MR, Banavali N, Li H, Belfort M (2018), Mycobacterial DnaB helicase intein as oxidative stress sensor, Nat Comm. 9:4363 | DOI: 10.1038/s41467-018-06554-x.

2017

1. Li Z, Brecher M, Zhang J, Sakamuru S, Liu B, Huang R, Koetzner CA, Allen CA, Jones SA, Deng YQ, Chen H, Gao F, Qin CF, Lin Q, Banavali N, Zhou J, Boles N, Xia M, Kramer LD, Li H (2017), Existing drugs as potent and broad-spectrum inhibitors for Zika virus by targeting NS2B-NS3 interaction, Cell Research, 27, 1046-1064.
2. Brecher M., Li Z., Liu B., Zhang J., Koetzner C.A., Alifarag A., Jones S.A., Lin Q., Kramer LD, Li H (2017), A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease, Plos Pathogens, 13(5): e1006411.

2016

1. Chan H, Pearson S, Green CM, Li Z, Zhang J, Belfort G, Shekhtman A, Li H, Belfort M. (2016) Exploring intein inhibition by platinum compounds as an antimicrobial strategy. J Biol Chem. 291, 22661–70

2015

1. Califano D, Cho JJ, Yang Q, Bhandoola A, Li H and Avram D. (2015) Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II, Immunity 43, 354-68

2014

1. Shio MT, Hassan GS, Shah WA, Nadiri A, Fakhry YE, Li H, Walid M (2014) Coexpression of TLR2 or TLR4 with HLA-DR potentiates the superantigenic activities of Mycoplasma arthritidis-derived mitogen, J. Immunol. 192(6): 2543-50. PMID: 24493819.

2013

1. Liu LH, Chen H, Brecher MB, Li Z, Wei B, Nandi B, Zhang J, Ling H, Winslow GM, Braun J, Li H (2013) Pfit is a structurally novel Crohn’s disease-associated superantigen, PloS Pathogens, 9(12):e1003837. DOI: 10.1371/journal.ppat.1003837
2. Li Y, Kong YJ, Zhou ZM, Chen H, Wang ZH, Hsieh YC, Zhao D, Zhi X, HuangJ, Zhang J, Li H, Chen C (2013) The HECTD3 E3 Ubiquitin Ligase Facilitates Cancer Cell Survival by Promoting K63-linked Polyubiquitination of Caspase-8, Cell Death and Disease 4, e935; doi:10.1038/cddis.2013.464.
3. Chen H, Liu LH, JonesSA, Banavali N, Kass J, Li Z, ZhangJ, Kramer LD, Ghosh AK, Li H(2013) Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs, Antiviral Res. 97, 232-9.

2010

1. Dong H, Liu L, Zou G, Zhao Y, Li Z, Lim SP, Shi PY, Li H (2010). Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase. J Biol Chem. 85: 32586-95.

2008

1. Dong HP, Ren SP, Zhang B, Zhou YS, Puig-Basagoiti F, Li H and Shi PY (2008). West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a Substrate repositioning mechanism. J. Virol, 82, 4295-307.

2007

1. Zhou Y, Ray D, Zhao Y, Dong H, Ren S, Li Z, Guo Y, Bernard KA, Shi PY & Li H (2007). Structure and function of flavivirus NS5 methyltransferase. J Virol. 81, 3891-3903.
2. LM Wang, YW Zhao, Zh. Li, Y. Guo, D.M. Kranz, W Mourad, H Li(2007), Crystal structure of a complete ternary complex between TCR, superantigen, and Class II MHC molecule, Nature Structure & Molecular Biology 14, 169-171.

2006

1. D. Ray, A. Shah, YW Zhao, M. Tilgner, Y. Guo, HP Dong, T.S. Deas, H Li, and PY Shi (2006), West Nile Virus 5’-Cap Structure is Formed through Sequential Methylations of Guanine N-7 and Ribose 2’-OH positions by Non-Structural Protein 5, J. Virol. 80, 8362-70.

2004

1. Zhao, Y., Li, Zh., Drozd, SJ, Guo, Y., Mourad, W, and Li, H. (2004), Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex, Structure 12, 277-88.

2001

1. Li, Y., Li, H, Dimasi, N., McCormick, J.K., Martin, R., Schuck, P., Schlievert, P.M. and Mariuzza, R.A. (2001). Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity 14, 93-104.
2. Morita, C., Li, H, Lamphear, J.G., Rich, R.R., Fraser, J.D., Mariuzza, R.A. and Lee, H.K. (2001). Superantigen recognition by gd T cells: SEA recognition site for human Vg2 T cell receptors, Immunity 14, 331-344.

1998

1. Li, H, Lebedeva, M.I., Llera, A.S., Fields, B.A., Brenner, M.B. and Mariuzza, R.A.. (1998). Structure of the Vd domain of a human gd T cell antigen receptor. Nature 391, 502-506.
2. Li, H, Llera, A.S., Leder, L., Tsuchiya, D., Ysern, X., Schlievert, P.M., Karjalainen, K. and Mariuzza, R.A. (1998). Three-dimensional structure of the complex between a T-cell receptor b-chain and the superantigen SEB. Immunity 9, 807-816.

1996

1. Fields, B.A., Malchiodi, E.L., Li, H, Ysern, X., Stauffacher, C.V., Schlievert, P.M., Karjalainen, K. and Mariuzza, R.A. (1996). Crystal structure of a T cell receptor b-chain complexed with superantigen SEC3. Nature 384, 188-192.